The action of various agents upon the rabbit embryo.
نویسندگان
چکیده
I N the course of an investigation on the uptake of labelled ions by the rabbit embryo and its environment (Lutwak-Mann, Boursnell, & Bennett, 1960), experiments were done on pre-implantation blastocysts obtained from rabbits which had been treated parenterally with certain purine analogues. Histological examination of such blastocysts by the method of Moog & Lutwak-Mann (1958) showed that, as a result of treatment of the pregnant animals, the embryos had incurred severe damage chiefly localized in the embryonic disc. This observation prompted a wider study, reported below, of the action of various agents upon the early rabbit embryo, following their administration to the mother. Our investigation was chiefly concerned with the pre-implantation 6^-day-old blastocyst, but 5and 7-day embryos were also examined. At the same time we have studied the influence of some of these agents upon ovulation, fertilization, and cleavage, as well as on implantation and later stages of pregnancy. We believe that these findings should be included as they contribute to a fuller understanding of the mode of action of embryotoxic factors. The viability of cleaving eggs that had been placed for a few hours in the oviducts of rabbits under treatment with purine analogues, was also investigated; these eggs were subsequently transferred to normal permanent recipients, in which their development was studied at later stages of pregnancy (the eggtransfer experiments were carried out by C. E. A.). Some of our findings have already been briefly reported (Hay, Adams, & Lutwak-Mann, 1960).
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ورودعنوان ژورنال:
- Journal of embryology and experimental morphology
دوره 9 شماره
صفحات -
تاریخ انتشار 1961